Advanced Quantitative Fluorescence Microscopy to Probe the Molecular Dynamics of Viral Entry, Science Lab

Viral entry into the host cell requires the coordination of many cellular and viral proteins in a precise order. Modern microscopy techniques are now allowing researchers to investigate these interactions with higher spatiotemporal resolution than ever before. Here we present two examples from the field of HIV research that make use of an innovative quantitative imaging approach as well as cutting edge fluorescence lifetime-based confocal microscopy methods to gain novel insights into how HIV fuses to cell membranes and enters the cell.

Labeling of virus components for advanced, quantitative imaging analyses - Sakin - 2016 - FEBS Letters - Wiley Online Library

Labeling of virus components for advanced, quantitative imaging analyses - Sakin - 2016 - FEBS Letters - Wiley Online Library

Quantitative description of a contractile macromolecular machine

Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics - Laboratory Investigation

Fluorescence decay curves of the purified EGFP (a) and its mutants

Frontiers Molecular dynamics simulation of an entire cell

Precision Fluorescent Labeling of an Adeno‐Associated Virus Vector to Monitor the Viral Infection Pathway - Zhang - 2018 - Biotechnology Journal - Wiley Online Library

Viruses, Free Full-Text

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